ArmaGen (UCLA) Re-Engineers Erythropoietin for Stroke (11/5/2010)

ArmaGen provides platform technology solutions to the ‘blood-brain barrier’ problem. The company was founded in 2004 by Dr. William Pardridge, Professor of Medicine and Endocrinology at UCLA.

ArmaGen re-engineers erythropoietin for stroke. Erythropoietin (EPO) is a potent neuroprotective agent, which could be developed for treatment of acute stroke. However, EPO does not cross the blood-brain barrier (BBB), and the BBB is intact in the early hours after stroke when neuroprotection is still possible. AGT-115 is a re-engineered form of human EPO that crosses the BBB via receptor-mediated transport. EPO is fused to a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). read more

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